1ntn
From Proteopedia
(New page: 200px<br /><applet load="1ntn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ntn, resolution 1.9Å" /> '''THE CRYSTAL STRUCTURE...) |
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| - | [[Image:1ntn.gif|left|200px]]<br /><applet load="1ntn" size=" | + | [[Image:1ntn.gif|left|200px]]<br /><applet load="1ntn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ntn, resolution 1.9Å" /> | caption="1ntn, resolution 1.9Å" /> | ||
'''THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION'''<br /> | '''THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by | + | Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by vapor diffusion in sitting drops. The crystals have cell dimensions of a = 25.2 A, b = 75.6 A, c = 35.9 A, and are in space group P2(1)2(1)2(1). Three-dimensional data to 1.9 A have been recorded by a Syntex P2(1) automatic diffractometer. The atomic structure of the toxin has been determined by molecular replacement using the alpha-cobratoxin (alpha-CTX) as the search model. The position of 534 non-hydrogen protein atoms have been determined. The model contains 65 water molecules. Refinement has led to an R-factor of 19.3% at 1.9 A resolution. The secondary and tertiary structures of NTX-1 have been analyzed and a comparison with structure of the alpha-CTX has been made. |
==About this Structure== | ==About this Structure== | ||
| - | 1NTN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http:// | + | 1NTN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Betzel, C.]] | [[Category: Betzel, C.]] | ||
| - | [[Category: Mikhailov, A | + | [[Category: Mikhailov, A M.]] |
| - | [[Category: Nickitenko, A | + | [[Category: Nickitenko, A V.]] |
| - | [[Category: Vainshtein, B | + | [[Category: Vainshtein, B K.]] |
[[Category: Wilson, K.]] | [[Category: Wilson, K.]] | ||
[[Category: postsynaptic neurotoxin]] | [[Category: postsynaptic neurotoxin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:09:52 2008'' |
Revision as of 12:09, 21 February 2008
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THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION
Overview
Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by vapor diffusion in sitting drops. The crystals have cell dimensions of a = 25.2 A, b = 75.6 A, c = 35.9 A, and are in space group P2(1)2(1)2(1). Three-dimensional data to 1.9 A have been recorded by a Syntex P2(1) automatic diffractometer. The atomic structure of the toxin has been determined by molecular replacement using the alpha-cobratoxin (alpha-CTX) as the search model. The position of 534 non-hydrogen protein atoms have been determined. The model contains 65 water molecules. Refinement has led to an R-factor of 19.3% at 1.9 A resolution. The secondary and tertiary structures of NTX-1 have been analyzed and a comparison with structure of the alpha-CTX has been made.
About this Structure
1NTN is a Single protein structure of sequence from Naja oxiana. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution., Nickitenko AV, Michailov AM, Betzel C, Wilson KS, FEBS Lett. 1993 Apr 5;320(2):111-7. PMID:8458425
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