2o2f

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==About this Structure==
==About this Structure==
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2O2F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2F OCA].
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2O2F is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2F OCA].
==Reference==
==Reference==
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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL., Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW, J Med Chem. 2007 Feb 22;50(4):641-62. Epub 2007 Jan 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17256834 17256834]
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<ref group="xtra">PMID:17256834</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Belli, B A.]]
[[Category: Belli, B A.]]
[[Category: Bruncko, M.]]
[[Category: Bruncko, M.]]
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[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:29:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:56:44 2009''

Revision as of 12:56, 17 February 2009

Image:2o2f.png

Template:STRUCTURE 2o2f

Contents

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Template:ABSTRACT PUBMED 17256834

Disease

Known disease associated with this structure: Leukemia/lymphoma, B-cell OMIM:[151430]

About this Structure

2O2F is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62. Epub 2007 Jan 26. PMID:17256834 doi:http://dx.doi.org/10.1021/jm061152t

Page seeded by OCA on Tue Feb 17 14:56:44 2009

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