1gvf
From Proteopedia
(New page: 200px<br /> <applet load="1gvf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gvf, resolution 1.45Å" /> '''STRUCTURE OF TAGATO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GVF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, NA, PGH and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.40 4.1.2.40]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVF OCA]]. | + | 1GVF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, NA, PGH and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Tagatose-bisphosphate_aldolase Tagatose-bisphosphate aldolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.40 4.1.2.40]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVF OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Tagatose-bisphosphate aldolase]] | ||
[[Category: Hall, D.R.]] | [[Category: Hall, D.R.]] | ||
[[Category: Hunter, W.N.]] | [[Category: Hunter, W.N.]] | ||
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[[Category: zinc.]] | [[Category: zinc.]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:28:44 2007'' |
Revision as of 11:24, 30 October 2007
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STRUCTURE OF TAGATOSE-1,6-BISPHOSPHATE ALDOLASE
Overview
Tagatose-1,6-bisphosphate aldolase (TBPA) is a tetrameric class II, aldolase that catalyzes the reversible condensation of dihydroxyacetone, phosphate with glyceraldehyde 3-phosphate to produce tagatose, 1,6-bisphosphate. The high resolution (1.45 A) crystal structure of the, Escherichia coli enzyme, encoded by the agaY gene, complexed with, phosphoglycolohydroxamate (PGH) has been determined. Two subunits comprise, the asymmetric unit, and a crystallographic 2-fold axis generates the, functional tetramer. A complex network of hydrogen bonds position side, chains in the active site that is occupied by two cations. An unusual Na+, binding site is created using a pi interaction with Tyr183 in addition to, five oxygen ligands. The catalytic Zn2+ is five-coordinate using three, histidine ... [(full description)]
About this Structure
1GVF is a [Single protein] structure of sequence from [Escherichia coli] with ZN, NA, PGH and EDO as [ligands]. Active as [Tagatose-bisphosphate aldolase], with EC number [4.1.2.40]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases., Hall DR, Bond CS, Leonard GA, Watt CI, Berry A, Hunter WN, J Biol Chem. 2002 Jun 14;277(24):22018-24. Epub 2002 Apr 8. PMID:11940603
Page seeded by OCA on Tue Oct 30 13:28:44 2007
Categories: Escherichia coli | Single protein | Tagatose-bisphosphate aldolase | Hall, D.R. | Hunter, W.N. | EDO | NA | PGH | ZN | Lyase | Zinc.
