1t1p

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==About this Structure==
==About this Structure==
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1T1P is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1P OCA].
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1T1P is a 2 chains structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1P OCA].
==Reference==
==Reference==
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How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor., Huang K, Xu B, Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang S, Wang RY, Nakagawa SH, Theede AM, Whittaker J, De Meyts P, Katsoyannis PG, Weiss MA, J Mol Biol. 2004 Aug 6;341(2):529-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15276842 15276842]
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<ref group="xtra">PMID:15276842</ref><ref group="xtra">PMID:11123908</ref><ref group="xtra">PMID:9148904</ref><ref group="xtra">PMID:8448120</ref><ref group="xtra">PMID:7014485</ref><references group="xtra"/>
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Mutational analysis of invariant valine B12 in insulin: implications for receptor binding., Nakagawa SH, Tager HS, Steiner DF, Biochemistry. 2000 Dec 26;39(51):15826-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11123908 11123908]
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Alanine scanning mutagenesis of insulin., Kristensen C, Kjeldsen T, Wiberg FC, Schaffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS, J Biol Chem. 1997 May 16;272(20):12978-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9148904 9148904]
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Steric requirements at position B12 for high biological activity in insulin., Hu SQ, Burke GT, Schwartz GP, Ferderigos N, Ross JB, Katsoyannis PG, Biochemistry. 1993 Mar 16;32(10):2631-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8448120 8448120]
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[12-asparagine-B] human insulin. An analogue with modification in the hydrophobic core of insulin., Schwartz GP, Burke GT, Katsoyannis PG, Int J Pept Protein Res. 1981 Feb;17(2):243-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7014485 7014485]
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[[Category: Protein complex]]
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[[Category: Chu, Y C.]]
[[Category: Chu, Y C.]]
[[Category: Hu, S Q.]]
[[Category: Hu, S Q.]]
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[[Category: Thr-b12-dkp-insulin]]
[[Category: Thr-b12-dkp-insulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:30:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:31:31 2009''

Revision as of 15:31, 17 February 2009

Image:1t1p.png

Template:STRUCTURE 1t1p

NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES

Template:ABSTRACT PUBMED 15276842

About this Structure

1T1P is a 2 chains structure. Full experimental information is available from OCA.

Reference

  • Huang K, Xu B, Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang S, Wang RY, Nakagawa SH, Theede AM, Whittaker J, De Meyts P, Katsoyannis PG, Weiss MA. How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. J Mol Biol. 2004 Aug 6;341(2):529-50. PMID:15276842 doi:10.1016/j.jmb.2004.05.023
  • Nakagawa SH, Tager HS, Steiner DF. Mutational analysis of invariant valine B12 in insulin: implications for receptor binding. Biochemistry. 2000 Dec 26;39(51):15826-35. PMID:11123908
  • Kristensen C, Kjeldsen T, Wiberg FC, Schaffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS. Alanine scanning mutagenesis of insulin. J Biol Chem. 1997 May 16;272(20):12978-83. PMID:9148904
  • Hu SQ, Burke GT, Schwartz GP, Ferderigos N, Ross JB, Katsoyannis PG. Steric requirements at position B12 for high biological activity in insulin. Biochemistry. 1993 Mar 16;32(10):2631-5. PMID:8448120
  • Schwartz GP, Burke GT, Katsoyannis PG. [12-asparagine-B] human insulin. An analogue with modification in the hydrophobic core of insulin. Int J Pept Protein Res. 1981 Feb;17(2):243-55. PMID:7014485

Page seeded by OCA on Tue Feb 17 17:31:31 2009

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