1oun
From Proteopedia
(New page: 200px<br /><applet load="1oun" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oun, resolution 2.3Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1oun.jpg|left|200px]]<br /><applet load="1oun" size=" | + | [[Image:1oun.jpg|left|200px]]<br /><applet load="1oun" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1oun, resolution 2.3Å" /> | caption="1oun, resolution 2.3Å" /> | ||
'''CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)'''<br /> | '''CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Nuclear transport factor 2 (NTF2) facilitates protein transport into the | + | Nuclear transport factor 2 (NTF2) facilitates protein transport into the nucleus and interacts with both the small Ras-like GTPase Ran and nucleoporin p62. We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a putative catalytic Asp-His pair, which raises the possibility of an unanticipated enzymatic activity of the molecule that may have implications for the molecular mechanism of nuclear protein import. |
==About this Structure== | ==About this Structure== | ||
| - | 1OUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http:// | + | 1OUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bullock, T | + | [[Category: Bullock, T L.]] |
| - | [[Category: Stewart, M | + | [[Category: Stewart, M J.]] |
[[Category: nuclear transport protein]] | [[Category: nuclear transport protein]] | ||
[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:21:46 2008'' |
Revision as of 12:21, 21 February 2008
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CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)
Overview
Nuclear transport factor 2 (NTF2) facilitates protein transport into the nucleus and interacts with both the small Ras-like GTPase Ran and nucleoporin p62. We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a putative catalytic Asp-His pair, which raises the possibility of an unanticipated enzymatic activity of the molecule that may have implications for the molecular mechanism of nuclear protein import.
About this Structure
1OUN is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:8757804
Page seeded by OCA on Thu Feb 21 14:21:46 2008
