1w07
From Proteopedia
(New page: 200px<br /> <applet load="1w07" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w07, resolution 2.00Å" /> '''ARABIDOPSIS THALIAN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W07 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with CA, CL, PT and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W07 OCA]]. | + | 1W07 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with CA, CL, PT and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Acyl-CoA_oxidase Acyl-CoA oxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W07 OCA]]. |
==Reference== | ==Reference== | ||
Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism., Pedersen L, Henriksen A, J Mol Biol. 2005 Jan 21;345(3):487-500. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15581893 15581893] | Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism., Pedersen L, Henriksen A, J Mol Biol. 2005 Jan 21;345(3):487-500. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15581893 15581893] | ||
| + | [[Category: Acyl-CoA oxidase]] | ||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peroxisomal beta-oxidation]] | [[Category: peroxisomal beta-oxidation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:31:33 2007'' |
Revision as of 11:26, 30 October 2007
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ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1
Overview
The peroxisomal acyl-CoA oxidase family plays an essential role in lipid, metabolism by catalyzing the conversion of acyl-CoA into trans-2-enoyl-CoA, during fatty acid beta-oxidation. Here, we report the X-ray structure of, the FAD-containing Arabidopsis thaliana acyl-CoA oxidase 1 (ACX1), the, first three-dimensional structure of a plant acyl-CoA oxidase. Like other, acyl-CoA oxidases, the enzyme is a dimer and it has a fold resembling that, of mammalian acyl-CoA oxidase. A comparative analysis including mammalian, acyl-CoA oxidase and the related tetrameric mitochondrial acyl-CoA, dehydrogenases reveals a substrate-binding architecture that explains the, observed preference for long-chained, mono-unsaturated substrates in ACX1., Two anions are found at the ACX1 dimer interface and for ... [(full description)]
About this Structure
1W07 is a [Single protein] structure of sequence from [Arabidopsis thaliana] with CA, CL, PT and FAD as [ligands]. Active as [Acyl-CoA oxidase], with EC number [1.3.3.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism., Pedersen L, Henriksen A, J Mol Biol. 2005 Jan 21;345(3):487-500. PMID:15581893
Page seeded by OCA on Tue Oct 30 13:31:33 2007
