2o21

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==About this Structure==
==About this Structure==
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2O21 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O21 OCA].
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2O21 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O21 OCA].
==Reference==
==Reference==
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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL., Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW, J Med Chem. 2007 Feb 22;50(4):641-62. Epub 2007 Jan 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17256834 17256834]
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<ref group="xtra">PMID:17256834</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Belli, B A.]]
[[Category: Belli, B A.]]
[[Category: Bruncko, M.]]
[[Category: Bruncko, M.]]
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[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:09:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:56:45 2009''

Revision as of 19:56, 17 February 2009

Image:2o21.png

Template:STRUCTURE 2o21

Contents

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Template:ABSTRACT PUBMED 17256834

Disease

Known disease associated with this structure: Leukemia/lymphoma, B-cell OMIM:[151430]

About this Structure

2O21 is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62. Epub 2007 Jan 26. PMID:17256834 doi:http://dx.doi.org/10.1021/jm061152t

Page seeded by OCA on Tue Feb 17 21:56:45 2009

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