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1w0m
From Proteopedia
(New page: 200px<br /> <applet load="1w0m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w0m, resolution 2.5Å" /> '''TRIOSEPHOSPHATE ISOM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W0M is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermoproteus_tenax Thermoproteus tenax]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0M OCA]]. | + | 1W0M is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermoproteus_tenax Thermoproteus tenax]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0M OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermoproteus tenax]] | [[Category: Thermoproteus tenax]] | ||
| + | [[Category: Triose-phosphate isomerase]] | ||
[[Category: Hensel, R.]] | [[Category: Hensel, R.]] | ||
[[Category: Knura, T.]] | [[Category: Knura, T.]] | ||
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[[Category: triosephosphate isomerase]] | [[Category: triosephosphate isomerase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:31:57 2007'' |
Revision as of 11:27, 30 October 2007
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TRIOSEPHOSPHATE ISOMERASE FROM THERMOPROTEUS TENAX
Overview
Triosephophate isomerase (TIM) is a dimeric enzyme in eucarya, bacteria, and mesophilic archaea. In hyperthermophilic archaea, however, TIM exists, as a tetramer composed of monomers that are about 10% shorter than other, eucaryal and bacterial TIM monomers. We report here the crystal structure, of TIM from Thermoproteus tenax, a hyperthermophilic archaeon that has an, optimum growth temperature of 86 degrees C. The structure was determined, from both a hexagonal and an orthorhombic crystal form to resolutions of, 2.5A and 2.3A, and refined to R-factors of 19.7% and 21.5%, respectively., In both crystal forms, T.tenax TIM exists as a tetramer of the familiar, (betaalpha)(8)-barrel. In solution, however, and unlike other, hyperthermophilic TIMs, the T.tenax enzyme exhibits an equilibrium ... [(full description)]
About this Structure
1W0M is a [Single protein] structure of sequence from [Thermoproteus tenax] with PO4 as [ligand]. Active as [Triose-phosphate isomerase], with EC number [5.3.1.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature., Walden H, Taylor GL, Lorentzen E, Pohl E, Lilie H, Schramm A, Knura T, Stubbe K, Tjaden B, Hensel R, J Mol Biol. 2004 Sep 17;342(3):861-75. PMID:15342242
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