1w0k
From Proteopedia
(New page: 200px<br /> <applet load="1w0k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w0k, resolution 2.85Å" /> '''BERYLLIUM FLUORIDE ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W0K is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with MG, PO4, ADP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0K OCA]]. | + | 1W0K is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with MG, PO4, ADP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14]]. Structure known Active Site: PLP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0K OCA]]. |
==Reference== | ==Reference== | ||
The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride., Kagawa R, Montgomery MG, Braig K, Leslie AG, Walker JE, EMBO J. 2004 Jul 21;23(14):2734-44. Epub 2004 Jul 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15229653 15229653] | The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride., Kagawa R, Montgomery MG, Braig K, Leslie AG, Walker JE, EMBO J. 2004 Jul 21;23(14):2734-44. Epub 2004 Jul 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15229653 15229653] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: H(+)-transporting two-sector ATPase]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Braig, K.]] | [[Category: Braig, K.]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:32:19 2007'' |
Revision as of 11:27, 30 October 2007
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BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE
Overview
The structure of bovine F1-ATPase inhibited with ADP and beryllium, fluoride at 2.0 angstroms resolution contains two ADP.BeF3- complexes, mimicking ATP, bound in the catalytic sites of the beta(TP) and beta(DP), subunits. Except for a 1 angstrom shift in the guanidinium of alphaArg373, the conformations of catalytic side chains are very similar in both sites., However, the ordered water molecule that carries out nucleophilic attack, on the gamma-phosphate of ATP during hydrolysis is 2.6 angstroms from the, beryllium in the beta(DP) subunit and 3.8 angstroms away in the beta(TP), subunit, strongly indicating that the beta(DP) subunit is the, catalytically active conformation. In the structure of F1-ATPase with five, bound ADP molecules (three in alpha-subunits, one each in the beta(TP) ... [(full description)]
About this Structure
1W0K is a [Protein complex] structure of sequences from [Bos taurus] with MG, PO4, ADP and GOL as [ligands]. Active as [H(+)-transporting two-sector ATPase], with EC number [3.6.3.14]. Structure known Active Site: PLP. Full crystallographic information is available from [OCA].
Reference
The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride., Kagawa R, Montgomery MG, Braig K, Leslie AG, Walker JE, EMBO J. 2004 Jul 21;23(14):2734-44. Epub 2004 Jul 1. PMID:15229653
Page seeded by OCA on Tue Oct 30 13:32:19 2007
Categories: Bos taurus | H(+)-transporting two-sector ATPase | Protein complex | Braig, K. | Kagawa, R. | Leslie, A.G.W. | Montgomery, M.G. | Walker, J.E. | ADP | GOL | MG | PO4 | Atp phosphorylase | Atp phosphorylase (h+ transporting) | Atp synthase | Atp synthesis | Atp-binding | F1-atpase | F1fo atp synthase | Hydrolase
