1pho
From Proteopedia
(New page: 200px<br /><applet load="1pho" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pho, resolution 3.0Å" /> '''CRYSTAL STRUCTURES EX...) |
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| - | [[Image:1pho.gif|left|200px]]<br /><applet load="1pho" size=" | + | [[Image:1pho.gif|left|200px]]<br /><applet load="1pho" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1pho, resolution 3.0Å" /> | caption="1pho, resolution 3.0Å" /> | ||
'''CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS'''<br /> | '''CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Porins form aqueous channels that aid the diffusion of small hydrophilic | + | Porins form aqueous channels that aid the diffusion of small hydrophilic molecules across the outer membrane of Gram-negative bacteria. The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel beta-barrel containing a pore. A long loop inside the barrel contributes to a constriction of the channel where the charge distribution affects ion selectivity. The structures explain at the molecular level functional characteristics and their alterations by known mutations. |
==About this Structure== | ==About this Structure== | ||
| - | 1PHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1PHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Cowan, S | + | [[Category: Cowan, S W.]] |
| - | [[Category: Jansonius, J | + | [[Category: Jansonius, J N.]] |
[[Category: Schirmer, T.]] | [[Category: Schirmer, T.]] | ||
[[Category: outer membrane protein]] | [[Category: outer membrane protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:28:52 2008'' |
Revision as of 12:28, 21 February 2008
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CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS
Overview
Porins form aqueous channels that aid the diffusion of small hydrophilic molecules across the outer membrane of Gram-negative bacteria. The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel beta-barrel containing a pore. A long loop inside the barrel contributes to a constriction of the channel where the charge distribution affects ion selectivity. The structures explain at the molecular level functional characteristics and their alterations by known mutations.
About this Structure
1PHO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structures explain functional properties of two E. coli porins., Cowan SW, Schirmer T, Rummel G, Steiert M, Ghosh R, Pauptit RA, Jansonius JN, Rosenbusch JP, Nature. 1992 Aug 27;358(6389):727-33. PMID:1380671
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