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1w2d
From Proteopedia
(New page: 200px<br /> <applet load="1w2d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w2d, resolution 1.94Å" /> '''HUMAN INOSITOL (1,4...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W2D is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MN, SO4, ADP and 4IP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.7.127 2.1.7.127]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W2D OCA]]. | + | 1W2D is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MN, SO4, ADP and 4IP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferase Transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.7.127 2.1.7.127]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W2D OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferase]] | ||
[[Category: Gonzalez, B.]] | [[Category: Gonzalez, B.]] | ||
[[Category: Irvine, R.F.]] | [[Category: Irvine, R.F.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:33:02 2007'' |
Revision as of 11:28, 30 October 2007
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HUMAN INOSITOL (1,4,5)-TRISPHOSPHATE 3-KINASE COMPLEXED WITH MN2+/ADP/INS(1,3,4,5)P4
Overview
Mammalian cells produce a variety of inositol phosphates (InsPs), including Ins(1,4,5)P3 that serves both as a second messenger and as a, substrate for inositol polyphosphate kinases (IPKs), which further, phosphorylate it. We report the structure of an IPK, the human, Ins(1,4,5)P3 3-kinase-A, both free and in complexes with substrates and, products. This enzyme catalyzes transfer of a phosphate from ATP to the, 3-OH of Ins(1,4,5)P3, and its X-ray crystal structure provides a template, for understanding a broad family of InsP kinases. The catalytic domain, consists of three lobes. The N and C lobes bind ATP and resemble protein, and lipid kinases, despite insignificant sequence similarity. The third, lobe binds inositol phosphate and is a unique four-helix insertion in the, C lobe. This ... [(full description)]
About this Structure
1W2D is a [Single protein] structure of sequence from [Homo sapiens] with MN, SO4, ADP and 4IP as [ligands]. Active as [Transferase], with EC number [2.1.7.127]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase., Gonzalez B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL, Mol Cell. 2004 Sep 10;15(5):689-701. PMID:15350214
Page seeded by OCA on Tue Oct 30 13:33:02 2007
Categories: Homo sapiens | Single protein | Transferase | Gonzalez, B. | Irvine, R.F. | Schell, M.J. | Williams, R.L. | 4IP | ADP | MN | SO4 | Adp | Inositol phosphate kinase | Ip4
