1sgk
From Proteopedia
(New page: 200px<br /> <applet load="1sgk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sgk, resolution 2.3Å" /> '''NUCLEOTIDE-FREE DIPH...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1SGK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SGK OCA]]. | + | 1SGK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]]. Active as [[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SGK OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of nucleotide-free diphtheria toxin., Bell CE, Eisenberg D, Biochemistry. 1997 Jan 21;36(3):481-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9012663 9012663] | Crystal structure of nucleotide-free diphtheria toxin., Bell CE, Eisenberg D, Biochemistry. 1997 Jan 21;36(3):481-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9012663 9012663] | ||
[[Category: Corynephage beta]] | [[Category: Corynephage beta]] | ||
| + | [[Category: NAD(+)--diphthamide ADP-ribosyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bell, C.E.]] | [[Category: Bell, C.E.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:34:43 2007'' |
Revision as of 11:30, 30 October 2007
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NUCLEOTIDE-FREE DIPHTHERIA TOXIN
Overview
The crystal structure of diphtheria toxin (DT) in the absence of, nucleotide (nucleotide-free DT) has been determined at 2.3 A resolution to, a crystallographic R factor and free R factor of 18.2 and 28.2%, respectively. A comparison of this structure to the previously determined, structures of DT in complex with adenyly(3'-5')uridine monophosphate, (ApUp) and DT in complex with nicotinamide adenine dinucleotide (NAD), reveals that there are no significant movements of the two subdomains of, the catalytic (C) domain associated with dinucleotide binding. The side, chains of six residues within the active-site cleft, including Tyr65, Pro38, Tyr27, Thr23, Glu148, and Tyr54, show movements of up to 3 A upon, dinucleotide binding. In the structure of nucleotide-free DT, the, active-site loop ... [(full description)]
About this Structure
1SGK is a [Single protein] structure of sequence from [Corynephage beta]. Active as [NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [2.4.2.36]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Crystal structure of nucleotide-free diphtheria toxin., Bell CE, Eisenberg D, Biochemistry. 1997 Jan 21;36(3):481-8. PMID:9012663
Page seeded by OCA on Tue Oct 30 13:34:43 2007
