1wfb
From Proteopedia
| Line 20: | Line 20: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1WFB is a | + | 1WFB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Pseudopleuronectes_americanus Pseudopleuronectes americanus]. The December 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Antifreeze Proteins'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_12 10.2210/rcsb_pdb/mom_2009_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFB OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:7760940</ref><references group="xtra"/> | |
| + | [[Category: Antifreeze Proteins]] | ||
[[Category: Pseudopleuronectes americanus]] | [[Category: Pseudopleuronectes americanus]] | ||
| - | [[Category: | + | [[Category: RCSB PDB Molecule of the Month]] |
[[Category: Sicheri, F.]] | [[Category: Sicheri, F.]] | ||
[[Category: Yang, D S.C.]] | [[Category: Yang, D S.C.]] | ||
| + | [[Category: Antifreeze polypeptide]] | ||
[[Category: Ice binding protein]] | [[Category: Ice binding protein]] | ||
[[Category: Thermal hysteresis protein]] | [[Category: Thermal hysteresis protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 21 08:56:47 2010'' |
Revision as of 06:56, 21 January 2010
| |||||||||
| 1wfb, resolution 1.50Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-Standard Residues: | |||||||||
| Related: | 1wfa | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT-180 DEGREES C
Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look at its ice-binding features. These consist of four repeated ice-binding motifs, the side chains of which are inherently rigid or restrained by pair-wise side-chain interactions to form a flat binding surface. Elaborate amino- and carboxy-terminal cap structures are also present, which explain the protein's rich alpha-helical content in solution. We propose an ice-binding model that accounts for the binding specificity of the antifreeze protein along the <0112> axes of the (2021) ice planes.
Ice-binding structure and mechanism of an antifreeze protein from winter flounder., Sicheri F, Yang DS, Nature. 1995 Jun 1;375(6530):427-31. PMID:7760940
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1WFB is a 2 chains structure with sequences from Pseudopleuronectes americanus. The December 2009 RCSB PDB Molecule of the Month feature on Antifreeze Proteins by David Goodsell is 10.2210/rcsb_pdb/mom_2009_12. Full crystallographic information is available from OCA.
Reference
- Sicheri F, Yang DS. Ice-binding structure and mechanism of an antifreeze protein from winter flounder. Nature. 1995 Jun 1;375(6530):427-31. PMID:7760940 doi:http://dx.doi.org/10.1038/375427a0
Page seeded by OCA on Thu Jan 21 08:56:47 2010
