2fvd

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==About this Structure==
==About this Structure==
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2FVD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVD OCA].
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2FVD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVD OCA].
==Reference==
==Reference==
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Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-diflu oro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity., Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N, J Med Chem. 2006 Nov 2;49(22):6549-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17064073 17064073]
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<ref group="xtra">PMID:17064073</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Single protein]]
 
[[Category: Crowther, R L.]]
[[Category: Crowther, R L.]]
[[Category: Kammlott, R U.]]
[[Category: Kammlott, R U.]]
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[[Category: Cdk2 ligand]]
[[Category: Cdk2 ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:53:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:11:43 2009''

Revision as of 03:11, 18 February 2009

Template:STRUCTURE 2fvd

Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor

Template:ABSTRACT PUBMED 17064073

About this Structure

2FVD is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-diflu oro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J Med Chem. 2006 Nov 2;49(22):6549-60. PMID:17064073 doi:10.1021/jm0606138

Page seeded by OCA on Wed Feb 18 05:11:43 2009

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