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2c5l
From Proteopedia
(New page: 200px<br /> <applet load="2c5l" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c5l, resolution 1.90Å" /> '''STRUCTURE OF PLC EP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C5L is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG, GTP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C5L OCA]]. | + | 2C5L is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG, GTP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C5L OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Small monomeric GTPase]] | ||
[[Category: Bunney, T.D.]] | [[Category: Bunney, T.D.]] | ||
[[Category: Katan, M.]] | [[Category: Katan, M.]] | ||
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[[Category: ubiquitin superfold]] | [[Category: ubiquitin superfold]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:36:38 2007'' |
Revision as of 11:31, 30 October 2007
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STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS
Overview
Ras proteins signal to a number of distinct pathways by interacting with, diverse effectors. Studies of ras/effector interactions have focused on, three classes, Raf kinases, ral guanylnucleotide-exchange factors, and, phosphatidylinositol-3-kinases. Here we describe ras interactions with, another effector, the recently identified phospholipase C epsilon, (PLCepsilon). We solved structures of PLCepsilon RA domains (RA1 and RA2), by NMR and the structure of the RA2/ras complex by X-ray crystallography., Although the similarity between ubiquitin-like folds of RA1 and RA2 proves, that they are homologs, only RA2 can bind ras. Some of the features of the, RA2/ras interface are unique to PLCepsilon, while the ability to make, contacts with both switch I and II regions of ras is shared only ... [(full description)]
About this Structure
2C5L is a [Protein complex] structure of sequences from [Homo sapiens] with MG, GTP and GOL as [ligands]. Active as [Small monomeric GTPase], with EC number [3.6.5.2]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural and mechanistic insights into ras association domains of phospholipase C epsilon., Bunney TD, Harris R, Gandarillas NL, Josephs MB, Roe SM, Sorli SC, Paterson HF, Rodrigues-Lima F, Esposito D, Ponting CP, Gierschik P, Pearl LH, Driscoll PC, Katan M, Mol Cell. 2006 Feb 17;21(4):495-507. PMID:16483931
Page seeded by OCA on Tue Oct 30 13:36:38 2007
Categories: Homo sapiens | Protein complex | Small monomeric GTPase | Bunney, T.D. | Katan, M. | Pearl, L.H. | Roe, S.M. | GOL | GTP | MG | Disease mutation | Gtp-binding | Lipoprotein | Nucleotide-binding | Oncogene | Palmitate | Prenylation | Proto-oncogene | Ras | Signaling protein | Ubiquitin superfold
