1qf4
From Proteopedia
(New page: 200px<br /><applet load="1qf4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qf4, resolution 2.2Å" /> '''DESIGN, SYNTHESIS, AN...) |
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| - | [[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size=" | + | [[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qf4, resolution 2.2Å" /> | caption="1qf4, resolution 2.2Å" /> | ||
'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''<br /> | '''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Two relatively weak herbicides, hydantocidin phosphate and hadacidin were | + | Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined. |
==About this Structure== | ==About this Structure== | ||
| - | 1QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4, MG, GDP and RPD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http:// | + | 1QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=RPD:'>RPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chemla, P.]] | [[Category: Chemla, P.]] | ||
| - | [[Category: Cowan-Jacob, S | + | [[Category: Cowan-Jacob, S W.]] |
[[Category: Fonne-Pfister, R.]] | [[Category: Fonne-Pfister, R.]] | ||
[[Category: Gohda, K.]] | [[Category: Gohda, K.]] | ||
[[Category: Hanessian, S.]] | [[Category: Hanessian, S.]] | ||
| - | [[Category: Lu, P | + | [[Category: Lu, P P.]] |
[[Category: Prade, L.]] | [[Category: Prade, L.]] | ||
| - | [[Category: Sanceau, J | + | [[Category: Sanceau, J Y.]] |
[[Category: GDP]] | [[Category: GDP]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: synthetase]] | [[Category: synthetase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:49 2008'' |
Revision as of 12:38, 21 February 2008
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DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE
Overview
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
About this Structure
1QF4 is a Single protein structure of sequence from Escherichia coli with , , and as ligands. Active as Adenylosuccinate synthase, with EC number 6.3.4.4 Full crystallographic information is available from OCA.
Reference
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888
Page seeded by OCA on Thu Feb 21 14:38:49 2008
