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1qfm

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(New page: 200px<br /><applet load="1qfm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qfm, resolution 1.400&Aring;" /> '''PROLYL OLIGOPEPTIDA...)
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caption="1qfm, resolution 1.400&Aring;" />
'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE'''<br />
'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE'''<br />
==Overview==
==Overview==
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Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new, class of serine peptidases. The enzyme is involved in the maturation and, degradation of peptide hormones and neuropeptides, which relate to the, induction of amnesia. The 1.4 A resolution crystal structure is presented, here. The enzyme contains a peptidase domain with an alpha/beta hydrolase, fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the, central tunnel of an unusual beta propeller. This domain makes prolyl, oligopeptidase an oligopeptidase by excluding large structured peptides, from the active site. In this way, the propeller protects larger peptides, and proteins from proteolysis in the cytosol. The structure is also, obtained with a transition state inhibitor, which may facilitate drug, design to treat memory disorders.
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Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an alpha/beta hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual beta propeller. This domain makes prolyl oligopeptidase an oligopeptidase by excluding large structured peptides from the active site. In this way, the propeller protects larger peptides and proteins from proteolysis in the cytosol. The structure is also obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders.
==About this Structure==
==About this Structure==
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1QFM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SGL, SGM and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QFM OCA].
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1QFM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=SGL:'>SGL</scene>, <scene name='pdbligand=SGM:'>SGM</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFM OCA].
==Reference==
==Reference==
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[[Category: prolyl oligopeptidase]]
[[Category: prolyl oligopeptidase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:38:37 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:58 2008''

Revision as of 12:38, 21 February 2008

Image:1qfm.jpg

1qfm, resolution 1.400Å

Drag the structure with the mouse to rotate

PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE

Overview

Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an alpha/beta hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual beta propeller. This domain makes prolyl oligopeptidase an oligopeptidase by excluding large structured peptides from the active site. In this way, the propeller protects larger peptides and proteins from proteolysis in the cytosol. The structure is also obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders.

About this Structure

1QFM is a Single protein structure of sequence from Sus scrofa with , and as ligands. Active as Prolyl oligopeptidase, with EC number 3.4.21.26 Full crystallographic information is available from OCA.

Reference

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis., Fulop V, Bocskei Z, Polgar L, Cell. 1998 Jul 24;94(2):161-70. PMID:9695945

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