2aaz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 20: Line 20:
==About this Structure==
==About this Structure==
-
2AAZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Filobasidiella_neoformans Filobasidiella neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAZ OCA].
+
2AAZ is a 16 chains structure of sequences from [http://en.wikipedia.org/wiki/Filobasidiella_neoformans Filobasidiella neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAZ OCA].
==Reference==
==Reference==
-
The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition., Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. Epub 2005, Sep 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16204883 16204883]
+
<ref group="xtra">PMID:16204883</ref><ref group="xtra">PMID:10377217</ref><ref group="xtra">PMID:9931028</ref><references group="xtra"/>
-
 
+
-
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition., Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P, J Med Chem. 1999 Jun 17;42(12):2112-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10377217 10377217]
+
-
 
+
-
Structure-based design of inhibitors specific for bacterial thymidylate synthase., Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP, Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9931028 9931028]
+
[[Category: Filobasidiella neoformans]]
[[Category: Filobasidiella neoformans]]
-
[[Category: Single protein]]
 
[[Category: Thymidylate synthase]]
[[Category: Thymidylate synthase]]
[[Category: Anderson, A C.]]
[[Category: Anderson, A C.]]
Line 42: Line 37:
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:13:43 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:00:55 2009''

Revision as of 07:00, 18 February 2009

Image:2aaz.png

Template:STRUCTURE 2aaz

Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate

Template:ABSTRACT PUBMED 16204883

About this Structure

2AAZ is a 16 chains structure of sequences from Filobasidiella neoformans. Full crystallographic information is available from OCA.

Reference

  • Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. Epub 2005, Sep 28. PMID:16204883 doi:10.1107/S0907444905022638
  • Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P. Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem. 1999 Jun 17;42(12):2112-24. PMID:10377217 doi:10.1021/jm9900016
  • Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:9931028 doi:10.1021/bi9815896

Page seeded by OCA on Wed Feb 18 09:00:55 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2aaz"
Personal tools