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2vuk
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| + | Targeted rescue of a destabilized mutant of p53 by an in silico screened drug., Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR, Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. Epub 2008 Jul 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18650397 18650397] | ||
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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs., Joerger AC, Ang HC, Fersht AR, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17015838 17015838] | Structural basis for understanding oncogenic p53 mutations and designing rescue drugs., Joerger AC, Ang HC, Fersht AR, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17015838 17015838] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Zinc]] | [[Category: Zinc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 13:45:33 2008'' |
Revision as of 10:45, 13 August 2008
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083
Template:ABSTRACT PUBMED 18650397
About this Structure
2VUK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug., Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR, Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. Epub 2008 Jul 23. PMID:18650397
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs., Joerger AC, Ang HC, Fersht AR, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Page seeded by OCA on Wed Aug 13 13:45:33 2008
Categories: Homo sapiens | Single protein | Boeckler, F M. | Fersht, A R. | Joerger, A C. | Acetylation | Activator | Alternative splicing | Anti-oncogene | Apoptosis | Cancer | Cell cycle | Covalent protein-rna linkage | Cytoplasm | Disease mutation | Dna binding | Dna-binding | Dna-binding protein | Endoplasmic reticulum | Glycoprotein | Host-virus interaction | Li-fraumeni syndrome | Metal binding | Metal-binding | Methylation | Nuclear protein | Nucleus | P53 dna- binding domain | Phosphoprotein | Polymorphism | Protein stabilization | Second-site suppressor mutation | Small-molecule drug | Superstable mutant | Surface crevice | Transcription | Transcription regulation | Tumor suppressor | Ubl conjugation | Virtual screening | Zinc
