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2jg4

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(New page: 200px<br /> <applet load="2jg4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jg4, resolution 2.80&Aring;" /> '''SUBSTRATE-FREE IDE ...)
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==About this Structure==
==About this Structure==
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2JG4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and DIO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JG4 OCA]].
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2JG4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and DIO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Insulysin Insulysin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JG4 OCA]].
==Reference==
==Reference==
Structure of Substrate-free Human Insulin-degrading Enzyme (IDE) and Biophysical Analysis of ATP-induced Conformational Switch of IDE., Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ, J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17613531 17613531]
Structure of Substrate-free Human Insulin-degrading Enzyme (IDE) and Biophysical Analysis of ATP-induced Conformational Switch of IDE., Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ, J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17613531 17613531]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Insulysin]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Malito, E.]]
[[Category: Malito, E.]]
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[[Category: zinc]]
[[Category: zinc]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:54:34 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:40:10 2007''

Revision as of 11:35, 30 October 2007

Image:2jg4.gif

2jg4, resolution 2.80Å

Drag the structure with the mouse to rotate

SUBSTRATE-FREE IDE STRUCTURE IN ITS CLOSED CONFORMATION

Overview

Insulin-degrading enzyme (IDE) is a zinc metalloprotease that hydrolyzes, amyloid-beta (Abeta) and insulin, which are peptides associated with, Alzheimer disease (AD) and diabetes, respectively. Our previous structural, analysis of substrate-bound human 113-kDa IDE reveals that the N- and, C-terminal domains of IDE, IDE-N and IDE-C, make substantial contact to, form an enclosed catalytic chamber to entrap its substrates. Furthermore, IDE undergoes a switch between the closed and open conformations for, catalysis. Here we report a substrate-free IDE structure in its closed, conformation, revealing the molecular details of the active conformation, of the catalytic site of IDE and new insights as to how the closed, conformation of IDE may be kept in its resting, inactive conformation. We, ... [(full description)]

About this Structure

2JG4 is a [Single protein] structure of sequence from [Homo sapiens] with ZN and DIO as [ligands]. Active as [Insulysin], with EC number [3.4.24.56]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of Substrate-free Human Insulin-degrading Enzyme (IDE) and Biophysical Analysis of ATP-induced Conformational Switch of IDE., Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ, J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531

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