1qzm
From Proteopedia
(New page: 200px<br /><applet load="1qzm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qzm, resolution 1.90Å" /> '''alpha-domain of ATPa...) |
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| - | [[Image:1qzm.gif|left|200px]]<br /><applet load="1qzm" size=" | + | [[Image:1qzm.gif|left|200px]]<br /><applet load="1qzm" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1qzm, resolution 1.90Å" /> | caption="1qzm, resolution 1.90Å" /> | ||
'''alpha-domain of ATPase'''<br /> | '''alpha-domain of ATPase'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QZM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] Full crystallographic information is available from [http:// | + | 1QZM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: aaa+ protein]] | [[Category: aaa+ protein]] | ||
[[Category: atp-dependent protease]] | [[Category: atp-dependent protease]] | ||
| + | [[Category: hydrolase]] | ||
[[Category: oligomerization domain]] | [[Category: oligomerization domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:01:52 2008'' |
Revision as of 10:01, 23 January 2008
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alpha-domain of ATPase
Overview
The crystal structure of the small, mostly helical alpha domain of the, AAA+ module of the Escherichia coli ATP-dependent protease Lon has been, solved by single isomorphous replacement combined with anomalous, scattering and refined at 1.9A resolution to a crystallographic R factor, of 17.9%. This domain, comprising residues 491-584, was obtained by, chymotrypsin digestion of the recombinant full-length protease. The alpha, domain of Lon contains four alpha helices and two parallel strands and, resembles similar domains found in a variety of ATPases and helicases, including the oligomeric proteases HslVU and ClpAP. The highly conserved, "sensor-2" Arg residue is located at the beginning of the third helix., Detailed comparison with the structures of 11 similar domains established, the putative location of the nucleotide-binding site in this first, fragment of Lon for which a crystal structure has become available.
About this Structure
1QZM is a Single protein structure of sequence from Escherichia coli. Active as Endopeptidase La, with EC number 3.4.21.53 Full crystallographic information is available from OCA.
Reference
Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution., Botos I, Melnikov EE, Cherry S, Khalatova AG, Rasulova FS, Tropea JE, Maurizi MR, Rotanova TV, Gustchina A, Wlodawer A, J Struct Biol. 2004 Apr-May;146(1-2):113-22. PMID:15037242
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