2bey
From Proteopedia
(New page: 200px<br /> <applet load="2bey" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bey" /> '''SOLUTION STRUCTURE OF A NOVEL C2 SYMMETRICA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BEY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BEY OCA]]. | + | 2BEY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]]. Structure known Active Site: P1A. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BEY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: symmetry]] | [[Category: symmetry]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:42:15 2007'' |
Revision as of 11:37, 30 October 2007
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SOLUTION STRUCTURE OF A NOVEL C2 SYMMETRICAL BIFUNCTIONAL BICYCLIC INHIBITOR BASED ON SFTI-1
Overview
A novel bifunctional bicyclic inhibitor has been created that combines, features both from the Bowman-Birk inhibitor (BBI) proteins, which have, two distinct inhibitory sites, and from sunflower trypsin inhibitor-1, (SFTI-1), which has a compact bicyclic structure. The inhibitor was, designed by fusing together a pair of reactive loops based on a sequence, derived from SFTI-1 to create a backbone-cyclized disulfide-bridged 16-mer, peptide. This peptide has two symmetrically spaced trypsin binding sites., Its synthesis and biological activity have been reported in a previous, communication [Jaulent and Leatherbarrow, 2004, PEDS 17, 681]. In the, present study we have examined the three-dimensional structure of the, molecule. We find that the new inhibitor, which has a symmetrical 8-mer, ... [(full description)]
About this Structure
2BEY is a [Single protein] structure of sequence from [[1]]. Structure known Active Site: P1A. Full crystallographic information is available from [OCA].
Reference
Solution structure of a novel C2-symmetrical bifunctional bicyclic inhibitor based on SFTI-1., Jaulent AM, Brauer AB, Matthews SJ, Leatherbarrow RJ, J Biomol NMR. 2005 Sep;33(1):57-62. PMID:16222558
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