3bys

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[[Image:3bys.jpg|left|200px]]
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===co-crystal structure of Lck and aminopyrimidine amide 10b===
===co-crystal structure of Lck and aminopyrimidine amide 10b===
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The line below this paragraph, {{ABSTRACT_PUBMED_18321037}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18321037 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18321037}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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3BYS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA].
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3BYS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA].
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==Reference==
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Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18321037 18321037]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Single protein]]
 
[[Category: Huang, X.]]
[[Category: Huang, X.]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
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[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:14:01 2008''

Revision as of 07:14, 31 December 2008

Image:3bys.png

Template:STRUCTURE 3bys

Contents

co-crystal structure of Lck and aminopyrimidine amide 10b

Template:ABSTRACT PUBMED 18321037

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3BYS is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037

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