2bex
From Proteopedia
(New page: 200px<br /> <applet load="2bex" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bex, resolution 1.99Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BEX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MAK and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BEX OCA]]. | + | 2BEX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MAK and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BEX OCA]]. |
==Reference== | ==Reference== | ||
Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor., Iyer S, Holloway DE, Kumar K, Shapiro R, Acharya KR, J Mol Biol. 2005 Apr 1;347(3):637-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15755456 15755456] | Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor., Iyer S, Holloway DE, Kumar K, Shapiro R, Acharya KR, J Mol Biol. 2005 Apr 1;347(3):637-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15755456 15755456] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Pancreatic ribonuclease]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: x-ray crystallography]] | [[Category: x-ray crystallography]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:42:43 2007'' |
Revision as of 11:38, 30 October 2007
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CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION
Overview
Placental ribonuclease inhibitor (RI) binds diverse mammalian RNases with, dissociation constants that are in the femtomolar range. Previous studies, on the complexes of RI with RNase A and angiogenin revealed that RI, utilises largely distinctive interactions to achieve high affinity for, these two ligands. Here we report a 2.0 angstroms resolution crystal, structure of RI in complex with a third ligand, eosinophil-derived, neurotoxin (EDN), and a mutational analysis based on this structure. The, RI-EDN interface is more extensive than those of the other two complexes, and contains a considerably larger set of interactions. Few of the, contacts present in the RI-angiogenin complex are replicated; the, correspondence to the RI-RNase A complex is somewhat greater, but still, modest. The ... [(full description)]
About this Structure
2BEX is a [Protein complex] structure of sequences from [Homo sapiens] with MAK and GOL as [ligands]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor., Iyer S, Holloway DE, Kumar K, Shapiro R, Acharya KR, J Mol Biol. 2005 Apr 1;347(3):637-55. PMID:15755456
Page seeded by OCA on Tue Oct 30 13:42:43 2007
Categories: Homo sapiens | Pancreatic ribonuclease | Protein complex | Acharya, K.R. | Holloway, D.E. | Iyer, S. | Kumar, K. | Shapiro, R. | GOL | MAK | Eosinophil derived neurotoxin | Luecine-rich repeats | Molecular recognition | Protein-protein interaction | Ribonuclease inhibitor | Rnase 2 | X-ray crystallography
