1ruv
From Proteopedia
(New page: 200px<br /> <applet load="1ruv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ruv, resolution 1.25Å" /> '''RIBONUCLEASE A-URID...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1RUV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with UVC and TBU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RUV OCA]]. | + | 1RUV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with UVC and TBU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RUV OCA]]. |
==Reference== | ==Reference== | ||
X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution., Ladner JE, Wladkowski BD, Svensson LA, Sjolin L, Gilliland GL, Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):290-301. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15299932 15299932] | X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution., Ladner JE, Wladkowski BD, Svensson LA, Sjolin L, Gilliland GL, Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):290-301. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15299932 15299932] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: Pancreatic ribonuclease]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Gilliland, G.L.]] | [[Category: Gilliland, G.L.]] | ||
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[[Category: signal]] | [[Category: signal]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:42:45 2007'' |
Revision as of 11:38, 30 October 2007
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RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A)
Overview
The X-ray crystal structure of a uridine vanadate-ribonuclease A complex, has been determined at 1.3 A resolution. The resulting structure includes, all 124 amino-acid residues, a uridine vanadate, 131 water molecules, and, a single bound 2-methyl-2-propanol. Side chains of 11 surface residues, showing discrete disorder were modeled with multiple conformations. The, final crystallographic R factor is 0.197. Structures obtained from, high-level ab initio quantum calculations of model anionic oxyvanadate, compounds were used to probe the effects of starting structure on the, refinement process and final structure of the penta-coordinate phosphorane, analog, uridine vanadate. The least-squares refinement procedure gave rise, to the same final structure of the inhibitor despite significantly, ... [(full description)]
About this Structure
1RUV is a [Single protein] structure of sequence from [Bos taurus] with UVC and TBU as [ligands]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
Reference
X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution., Ladner JE, Wladkowski BD, Svensson LA, Sjolin L, Gilliland GL, Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):290-301. PMID:15299932
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