1hpj
From Proteopedia
(New page: 200px<br /> <applet load="1hpj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hpj" /> '''SOLUTION NMR STRUCTURE OF THE HUMAN PLASMIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HPJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HPJ OCA]]. | + | 1HPJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Plasmin Plasmin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7]]. Structure known Active Site: AHA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HPJ OCA]]. |
==Reference== | ==Reference== | ||
Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1., Rejante MR, Llinas M, Eur J Biochem. 1994 May 1;221(3):939-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8181476 8181476] | Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1., Rejante MR, Llinas M, Eur J Biochem. 1994 May 1;221(3):939-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8181476 8181476] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Plasmin]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Llinas, M.]] | [[Category: Llinas, M.]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:43:14 2007'' |
Revision as of 11:38, 30 October 2007
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SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN COMPLEXED WITH 6-AMINOHEXANOIC ACID AT PH 5.3, 310K, DERIVED FROM RANDOMLY GENERATED STRUCTURES USING SIMULATED ANNEALING, 12 STRUCTURES
Overview
The solution structure of the human plasminogen kringle 1 domain complexed, to the antifibrinolytic drug 6-aminohexanoic acid (epsilon Ahx) was, obtained on the basis of 1H-NMR spectroscopic data and dynamical simulated, annealing calculations. Two sets of structures were derived starting from, (a) random coil conformations and (b) the (mutated) crystallographic, structure of the homologous prothrombin kringle 1. The two sets display, essentially the same backbone folding (pairwise root-mean-square, deviation, 0.15 nm) indicating that, regardless of the initial structure, the data is sufficient to locate a conformation corresponding to an, essentially unique energy minimum. The conformations of residues connected, to prolines were localized to energetically preferred regions of the, ... [(full description)]
About this Structure
1HPJ is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Plasmin], with EC number [3.4.21.7]. Structure known Active Site: AHA. Full crystallographic information is available from [OCA].
Reference
Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1., Rejante MR, Llinas M, Eur J Biochem. 1994 May 1;221(3):939-49. PMID:8181476
Page seeded by OCA on Tue Oct 30 13:43:14 2007
