1ryt
From Proteopedia
(New page: 200px<br /><applet load="1ryt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ryt, resolution 2.1Å" /> '''RUBRERYTHRIN'''<br />...) |
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| - | [[Image:1ryt.gif|left|200px]]<br /><applet load="1ryt" size=" | + | [[Image:1ryt.gif|left|200px]]<br /><applet load="1ryt" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ryt, resolution 2.1Å" /> | caption="1ryt, resolution 2.1Å" /> | ||
'''RUBRERYTHRIN'''<br /> | '''RUBRERYTHRIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the structure of rubrerythrin, a non-haem iron protein | + | We have determined the structure of rubrerythrin, a non-haem iron protein from the anaerobic sulphate-reducing bacterium, Desulfovibrio vulgaris (Hildenborough), by X-ray crystallography. The structure reveals a tetramer of two-domain subunits. Each subunit contains a four-helix bundle surrounding a diiron-oxo site and a C-terminal rubredoxin-like FeS4 domain. The diiron-oxo site contains a larger number of carboxylate ligands and a higher degree of solvent exposure than do those in other diiron-oxo proteins. The four-helix bundle of rubrerythrin closely resembles those of the ferritin and bacterioferritin subunits, suggesting a relationship among these proteins-consistent with the recently demonstrated ferroxidase activity of rubrerythrin. |
==About this Structure== | ==About this Structure== | ||
| - | 1RYT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris] with FE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1RYT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris] with <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Demare, F.]] | [[Category: Demare, F.]] | ||
| - | [[Category: Kurtz, D | + | [[Category: Kurtz, D M.]] |
[[Category: Nordlund, P.]] | [[Category: Nordlund, P.]] | ||
[[Category: FE]] | [[Category: FE]] | ||
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[[Category: iron]] | [[Category: iron]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:07 2008'' |
Revision as of 12:56, 21 February 2008
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RUBRERYTHRIN
Overview
We have determined the structure of rubrerythrin, a non-haem iron protein from the anaerobic sulphate-reducing bacterium, Desulfovibrio vulgaris (Hildenborough), by X-ray crystallography. The structure reveals a tetramer of two-domain subunits. Each subunit contains a four-helix bundle surrounding a diiron-oxo site and a C-terminal rubredoxin-like FeS4 domain. The diiron-oxo site contains a larger number of carboxylate ligands and a higher degree of solvent exposure than do those in other diiron-oxo proteins. The four-helix bundle of rubrerythrin closely resembles those of the ferritin and bacterioferritin subunits, suggesting a relationship among these proteins-consistent with the recently demonstrated ferroxidase activity of rubrerythrin.
About this Structure
1RYT is a Single protein structure of sequence from Desulfovibrio vulgaris with as ligand. Full crystallographic information is available from OCA.
Reference
The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains., deMare F, Kurtz DM Jr, Nordlund P, Nat Struct Biol. 1996 Jun;3(6):539-46. PMID:8646540
Page seeded by OCA on Thu Feb 21 14:56:07 2008
