1sdb
From Proteopedia
(New page: 200px<br /><applet load="1sdb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sdb, resolution 1.65Å" /> '''PORCINE DESB1-2 DESP...) |
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| - | [[Image:1sdb.jpg|left|200px]]<br /><applet load="1sdb" size=" | + | [[Image:1sdb.jpg|left|200px]]<br /><applet load="1sdb" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1sdb, resolution 1.65Å" /> | caption="1sdb, resolution 1.65Å" /> | ||
'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''<br /> | '''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures | + | Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility. |
==About this Structure== | ==About this Structure== | ||
| - | 1SDB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http:// | + | 1SDB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Diao, J | + | [[Category: Diao, J S.]] |
| - | [[Category: Liang, D | + | [[Category: Liang, D C.]] |
[[Category: hormone]] | [[Category: hormone]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:00:21 2008'' |
Revision as of 13:00, 21 February 2008
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PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN
Overview
Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.
About this Structure
1SDB is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.
Reference
Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution., Diao JS, Wan ZL, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880
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