1slc
From Proteopedia
(New page: 200px<br /><applet load="1slc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1slc, resolution 2.15Å" /> '''X-RAY CRYSTALLOGRAPH...) |
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| - | [[Image:1slc.gif|left|200px]]<br /><applet load="1slc" size=" | + | [[Image:1slc.gif|left|200px]]<br /><applet load="1slc" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1slc, resolution 2.15Å" /> | caption="1slc, resolution 2.15Å" /> | ||
'''X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES'''<br /> | '''X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Galectins are beta-galactoside-binding proteins that occur intra- and | + | Galectins are beta-galactoside-binding proteins that occur intra- and extracellularly in many animal tissues. They have been proposed to form networks of glycoconjugates on the cell surface, where they may modulate various cell response pathways such as growth, activation and adhesion. The high resolution X-ray crystallographic analyses of three crystal forms of bovine galectin-1 in complex with biantennary saccharides of N-acetyllactosamine type reveal infinite chains of lectin dimers cross-linked through N-acetyllactosamine units located at the end of the oligosaccharide antenna. The oligosaccharide adopts a different low energy conformation in each of the three crystal forms. |
==About this Structure== | ==About this Structure== | ||
| - | 1SLC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1SLC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SLC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: complex(lectin/saccharide)]] | [[Category: complex(lectin/saccharide)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:02:40 2008'' |
Revision as of 13:02, 21 February 2008
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X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES
Overview
Galectins are beta-galactoside-binding proteins that occur intra- and extracellularly in many animal tissues. They have been proposed to form networks of glycoconjugates on the cell surface, where they may modulate various cell response pathways such as growth, activation and adhesion. The high resolution X-ray crystallographic analyses of three crystal forms of bovine galectin-1 in complex with biantennary saccharides of N-acetyllactosamine type reveal infinite chains of lectin dimers cross-linked through N-acetyllactosamine units located at the end of the oligosaccharide antenna. The oligosaccharide adopts a different low energy conformation in each of the three crystal forms.
About this Structure
1SLC is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides., Bourne Y, Bolgiano B, Liao DI, Strecker G, Cantau P, Herzberg O, Feizi T, Cambillau C, Nat Struct Biol. 1994 Dec;1(12):863-70. PMID:7773775
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