1dap
From Proteopedia
(New page: 200px<br /> <applet load="1dap" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dap, resolution 2.2Å" /> '''C. GLUTAMICUM DAP DE...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DAP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]] with ACT and NDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.16 1.4.1.16]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DAP OCA]]. | + | 1DAP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]] with ACT and NDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Diaminopimelate_dehydrogenase Diaminopimelate dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.16 1.4.1.16]]. Structure known Active Sites: ACE, N1 and N2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DAP OCA]]. |
==Reference== | ==Reference== | ||
Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum., Scapin G, Reddy SG, Blanchard JS, Biochemistry. 1996 Oct 22;35(42):13540-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8885833 8885833] | Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum., Scapin G, Reddy SG, Blanchard JS, Biochemistry. 1996 Oct 22;35(42):13540-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8885833 8885833] | ||
[[Category: Corynebacterium glutamicum]] | [[Category: Corynebacterium glutamicum]] | ||
| + | [[Category: Diaminopimelate dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Blanchard, J.S.]] | [[Category: Blanchard, J.S.]] | ||
| Line 26: | Line 27: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:46:40 2007'' |
Revision as of 11:41, 30 October 2007
|
C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+
Overview
Diaminopimelate dehydrogenase catalyzes the NADPH-dependent reduction of, ammonia and L-2-amino-6-ketopimelate to form meso-diaminopimelate, the, direct precursor of L-lysine in the bacterial lysine biosynthetic pathway., Since mammals lack this metabolic pathway inhibitors of enzymes in this, pathway may be useful as antibiotics or herbicides. Diaminopimelate, dehydrogenase catalyzes the only oxidative deamination of an amino acid of, D configuration and must additionally distinguish between two chiral amino, acid centers on the same symmetric substrate. The Corynebacterium, glutamicum enzyme has been cloned, expressed in Escherichia coli, and, purified to homogeneity using standard biochemical procedures [Reddy, S., G., Scapin, G., & Blanchard, J. S. (1996) Proteins: Structure, ... [(full description)]
About this Structure
1DAP is a [Single protein] structure of sequence from [Corynebacterium glutamicum] with ACT and NDP as [ligands]. Active as [Diaminopimelate dehydrogenase], with EC number [1.4.1.16]. Structure known Active Sites: ACE, N1 and N2. Full crystallographic information is available from [OCA].
Reference
Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum., Scapin G, Reddy SG, Blanchard JS, Biochemistry. 1996 Oct 22;35(42):13540-51. PMID:8885833
Page seeded by OCA on Tue Oct 30 13:46:40 2007
