1ssk
From Proteopedia
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'''Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein'''<br /> | '''Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The severe acute respiratory syndrome (SARS) virus belongs to the | + | The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site. |
==About this Structure== | ==About this Structure== | ||
| - | 1SSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http:// | + | 1SSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human sars coronavirus]] | [[Category: Human sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Fesik, S | + | [[Category: Fesik, S W.]] |
[[Category: Gunasekera, A.]] | [[Category: Gunasekera, A.]] | ||
[[Category: Hajduk, P.]] | [[Category: Hajduk, P.]] | ||
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[[Category: Liu, Z.]] | [[Category: Liu, Z.]] | ||
[[Category: Mack, J.]] | [[Category: Mack, J.]] | ||
| - | [[Category: Olejniczak, E | + | [[Category: Olejniczak, E T.]] |
| - | [[Category: Petros, A | + | [[Category: Petros, A M.]] |
[[Category: Xu, N.]] | [[Category: Xu, N.]] | ||
[[Category: Yu, L.]] | [[Category: Yu, L.]] | ||
[[Category: nucleocapsid protein]] | [[Category: nucleocapsid protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:45 2008'' |
Revision as of 13:04, 21 February 2008
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Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein
Overview
The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.
About this Structure
1SSK is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein., Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET, Biochemistry. 2004 May 25;43(20):6059-63. PMID:15147189
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