1a7c
From Proteopedia
(New page: 200px<br /> <applet load="1a7c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a7c, resolution 1.95Å" /> '''HUMAN PLASMINOGEN A...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1A7C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A7C OCA]]. | + | 1A7C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: NUL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A7C OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: serine protease inhibitor]] | [[Category: serine protease inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:48:28 2007'' |
Revision as of 11:43, 30 October 2007
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HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE
Overview
BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) is an important, endogenous regulator of the fibrinolytic system. Reduction of PAI-1, activity has been shown to enhance dissolution of blood clots. Like other, serpins, PAI-1 binds covalently to a target serine protease, thereby, irreversibly inactivating the enzyme. During this process the exposed, reactive-centre loop of PAI-1 is believed to undergo a conformational, change becoming inserted into beta sheet A of the serpin. Incubation with, peptides from the reactive-centre loop transform serpins into a substrate, for their target protease. It has been hypothesised that these peptides, bind to beta sheet A, thereby hindering the conformational rearrangement, leading to loop insertion and formation of the stable serpin-protease, ... [(full description)]
About this Structure
1A7C is a [Single protein] structure of sequence from [Homo sapiens] with NAG as [ligand]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].
Reference
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide., Xue Y, Bjorquist P, Inghardt T, Linschoten M, Musil D, Sjolin L, Deinum J, Structure. 1998 May 15;6(5):627-36. PMID:9634700
Page seeded by OCA on Tue Oct 30 13:48:28 2007
