This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1t7s
From Proteopedia
(New page: 200px<br /><applet load="1t7s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t7s, resolution 2.80Å" /> '''Structural Genomics ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1t7s.gif|left|200px]]<br /><applet load="1t7s" size=" | + | [[Image:1t7s.gif|left|200px]]<br /><applet load="1t7s" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1t7s, resolution 2.80Å" /> | caption="1t7s, resolution 2.80Å" /> | ||
'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''<br /> | '''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Binding of the BAG domain to the eukaryotic chaperone heat-shock protein | + | Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain. |
==About this Structure== | ==About this Structure== | ||
| - | 1T7S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http:// | + | 1T7S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Bunzel, R.]] | [[Category: Bunzel, R.]] | ||
[[Category: Li, S.]] | [[Category: Li, S.]] | ||
| - | [[Category: Luan, C | + | [[Category: Luan, C H.]] |
[[Category: Luo, M.]] | [[Category: Luo, M.]] | ||
[[Category: Pruett, P.]] | [[Category: Pruett, P.]] | ||
| - | [[Category: SECSG, Southeast | + | [[Category: SECSG, Southeast Collaboratory for Structural Genomics.]] |
[[Category: Schormann, N.]] | [[Category: Schormann, N.]] | ||
[[Category: Symersky, J.]] | [[Category: Symersky, J.]] | ||
| Line 29: | Line 29: | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:10:48 2008'' |
Revision as of 13:10, 21 February 2008
|
Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein
Overview
Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
About this Structure
1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932
Page seeded by OCA on Thu Feb 21 15:10:48 2008
Categories: Caenorhabditis elegans | Single protein | Bunzel, R. | Li, S. | Luan, C H. | Luo, M. | Pruett, P. | SECSG, Southeast Collaboratory for Structural Genomics. | Schormann, N. | Symersky, J. | Zhang, Y. | Bag-1 cochaperone | Protein structure initiative | Psi | Secsg | Southeast collaboratory for structural genomics | Structural genomics
