1hfo
From Proteopedia
(New page: 200px<br /> <applet load="1hfo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hfo, resolution 1.65Å" /> '''THE STRUCTURE OF TH...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HFO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Trichinella_spiralis Trichinella spiralis]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HFO OCA]]. | + | 1HFO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Trichinella_spiralis Trichinella spiralis]]. Structure known Active Sites: DTA, DTB, DTC, DTD, DTE and DTF. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HFO OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tautomerase]] | [[Category: tautomerase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:49:24 2007'' |
Revision as of 11:44, 30 October 2007
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THE STRUCTURE OF THE MACROPHAGE MIGRATION INHIBITORY FACTOR FROM TRICHINELLA SPIRALIS.
Overview
cDNAs were obtained for macrophage migration-inhibitory factor, (MIF)/L-dopachrome methyl ester tautomerase homologues from the parasitic, nematodes Trichinella spiralis (TsMIF) and Trichuris trichiura (TtMIF)., The translated sequences, which were partly confirmed by sequencing of, proteolytic fragments, show 42 and 44% identity respectively with human or, mouse MIF, and are shorter by one C-terminal residue. Unlike vertebrate, MIF and MIF homologues of filarial nematodes, neither TsMIF nor TtMIF, contain cysteine residues. Soluble recombinant TsMIF, expressed in, Escherichia coli showed secondary structure (by CD spectroscopy) and, quaternary structure (by light-scattering and gel filtration) similar to, that of the trimeric mammalian MIFs and D-dopachrome tautomerase. The, catalytic ... [(full description)]
About this Structure
1HFO is a [Single protein] structure of sequence from [Trichinella spiralis]. Structure known Active Sites: DTA, DTB, DTC, DTD, DTE and DTF. Full crystallographic information is available from [OCA].
Reference
Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis., Tan TH, Edgerton SA, Kumari R, McAlister MS, Roe SM, Nagl S, Pearl LH, Selkirk ME, Bianco AE, Totty NF, Engwerda C, Gray CA, Meyer DJ, Biochem J. 2001 Jul 15;357(Pt 2):373-83. PMID:11439086
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