3eta

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3eta.jpg|left|200px]]
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The entry 3eta is ON HOLD until Paper Publication
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{{STRUCTURE_3eta| PDB=3eta | SCENE= }}
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Authors: Patnaik, S., Stevens, K., Gerding, R., Deanda, F., Shotwell, B., Tang, J., Hamajima, T., Nakamura, H., Leesnitzer, A., Hassell, A., Shewchuk, L., Kumar, R., Lei, H., Chamberlain, S.
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===Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor===
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Description: Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 22 10:18:14 2008''
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(as it appears on PubMed at http://www.pubmed.gov), where 19394223 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19394223}}
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==Disease==
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Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Leprechaunism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Rabson-Mendenhall syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]]
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==About this Structure==
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3ETA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETA OCA].
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==Reference==
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<ref group="xtra">PMID:19394223</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Chamberlain, S.]]
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[[Category: Deanda, F.]]
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[[Category: Gerding, R.]]
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[[Category: Hamajima, T.]]
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[[Category: Hassell, A.]]
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[[Category: Kumar, R.]]
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[[Category: Leesnitzer, A.]]
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[[Category: Lei, H.]]
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[[Category: Nakamura, H.]]
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[[Category: Patnaik, S.]]
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[[Category: Shewchuk, L.]]
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[[Category: Shotwell, B.]]
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[[Category: Stevens, K.]]
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[[Category: Tang, J.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Diabetes mellitus]]
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[[Category: Disease mutation]]
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[[Category: Glycoprotein]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:20:32 2009''

Revision as of 12:20, 27 May 2009

Image:3eta.jpg

Template:STRUCTURE 3eta

Contents

Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor

Template:ABSTRACT PUBMED 19394223

Disease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]

About this Structure

3ETA is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Patnaik S, Stevens KL, Gerding R, Deanda F, Shotwell JB, Tang J, Hamajima T, Nakamura H, Leesnitzer MA, Hassell AM, Shewchuck LM, Kumar R, Lei H, Chamberlain SD. Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3136-40. Epub 2009 Jan 6. PMID:19394223 doi:10.1016/j.bmcl.2008.12.110

Page seeded by OCA on Wed May 27 15:20:32 2009

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