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User:Wayne Decatur/Suppression of RNA Silencing by Viruses

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*[[2az0]] Flock house virus B2 protein
*[[2az0]] Flock house virus B2 protein
*[[2b9z]] Flock house virus B2 protein solution structure of protein only
*[[2b9z]] Flock house virus B2 protein solution structure of protein only
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[[Category: RNA Silencing]]
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[[Category: post-transcriptional gene silencing (PTGS)]]
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[[Category: Virus]]
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[[Category: Plant Virus]]
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[[Category: double-stranded RNA (dsRNA)]]
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[[Category: siRNA]]
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[[Category: Protein-rna complex]]
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[[Category: Rna double helix]]
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[[Category: Rna length recognition]]
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[[Category: Rnai]]

Revision as of 23:15, 25 October 2008

Background

RNA interference (RNAi) (also known as post-transcriptional gene silencing (PTGS) or RNA silencing) is an evolutionarily conserved cellular response to the presence of double-stranded (ds) RNA that functions as a gene inactivation system in many eukaryotes and relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses, several of which rely on double-stranded RNA for replication. Viruses have developed mechanisms to counteract RNAi by providing proteins that sequester siRNAs targeted against viral RNAs.

Several structures, listed below, have provided insight into the basis for the molecular interactions responsible for suppression of gene silencing (RNAi) by viruses.

Related Structures and Topics

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Wayne Decatur

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