1w6f
From Proteopedia
(New page: 200px<br /> <applet load="1w6f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w6f, resolution 2.100Å" /> '''ARYLAMINE N-ACETYL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W6F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]] with ISZ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6F OCA]]. | + | 1W6F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]] with ISZ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6F OCA]]. |
==Reference== | ==Reference== | ||
Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis., Sandy J, Holton S, Fullam E, Sim E, Noble M, Protein Sci. 2005 Mar;14(3):775-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15722451 15722451] | Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis., Sandy J, Holton S, Fullam E, Sim E, Noble M, Protein Sci. 2005 Mar;14(3):775-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15722451 15722451] | ||
| + | [[Category: Arylamine N-acetyltransferase]] | ||
[[Category: Mycobacterium smegmatis]] | [[Category: Mycobacterium smegmatis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tuberculosis]] | [[Category: tuberculosis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:49:58 2007'' |
Revision as of 11:45, 30 October 2007
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ARYLAMINE N-ACETYLTRANSFERASE FROM MYCOBACTERIUM SMEGMATIS WITH THE ANTI-TUBERCULAR DRUG ISONIAZID BOUND IN THE ACTIVE SITE.
Overview
Isoniazid is a frontline drug used in the treatment of tuberculosis (TB)., Isoniazid is a prodrug, requiring activation in the mycobacterial cell by, the catalase/peroxidase activity of the katG gene product. TB kills two, million people every year and the situation is getting worse due to the, increase in prevalence of HIV/AIDS and emergence of multidrug-resistant, strains of TB. Arylamine N-acetyltransferase (NAT) is a drug-metabolizing, enzyme (E.C. 2.1.3.5). NAT can acetylate isoniazid, transferring an acetyl, group from acetyl coenzyme A onto the terminal nitrogen of the drug, which, in its N-acetylated form is therapeutically inactive. The bacterium, responsible for TB, Mycobacterium tuberculosis, contains and expresses the, gene encoding the NAT protein. Isoniazid binds to the NAT ... [(full description)]
About this Structure
1W6F is a [Single protein] structure of sequence from [Mycobacterium smegmatis] with ISZ as [ligand]. Active as [Arylamine N-acetyltransferase], with EC number [2.3.1.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis., Sandy J, Holton S, Fullam E, Sim E, Noble M, Protein Sci. 2005 Mar;14(3):775-82. PMID:15722451
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