1thf
From Proteopedia
(New page: 200px<br /><applet load="1thf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1thf, resolution 1.45Å" /> '''CYCLASE SUBUNIT OF I...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1thf.jpg|left|200px]]<br /><applet load="1thf" size=" | + | [[Image:1thf.jpg|left|200px]]<br /><applet load="1thf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1thf, resolution 1.45Å" /> | caption="1thf, resolution 1.45Å" /> | ||
'''CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA'''<br /> | '''CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The atomic structures of two proteins in the histidine biosynthesis | + | The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1THF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1THF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THF OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| - | [[Category: Lang, D | + | [[Category: Lang, D A.]] |
[[Category: Wilmanns, M.]] | [[Category: Wilmanns, M.]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
| Line 22: | Line 22: | ||
[[Category: tim-barrel]] | [[Category: tim-barrel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:39 2008'' |
Revision as of 13:13, 21 February 2008
|
CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA
Overview
The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.
About this Structure
1THF is a Single protein structure of sequence from Thermotoga maritima with as ligand. Full crystallographic information is available from OCA.
Reference
Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion., Lang D, Thoma R, Henn-Sax M, Sterner R, Wilmanns M, Science. 2000 Sep 1;289(5484):1546-50. PMID:10968789
Page seeded by OCA on Thu Feb 21 15:13:39 2008
