3df0
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| + | Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains., Moldoveanu T, Gehring K, Green DR, Nature. 2008 Nov 20;456(7220):404-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19020622 19020622] | ||
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A Ca(2+) switch aligns the active site of calpain., Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL, Cell. 2002 Mar 8;108(5):649-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11893336 11893336] | A Ca(2+) switch aligns the active site of calpain., Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL, Cell. 2002 Mar 8;108(5):649-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11893336 11893336] | ||
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[[Category: Calpain-2]] | [[Category: Calpain-2]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: Alternative splicing]] | [[Category: Alternative splicing]] | ||
[[Category: C2-like domain]] | [[Category: C2-like domain]] | ||
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[[Category: Thiol protease inhibitor]] | [[Category: Thiol protease inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 3 20:14:20 2008'' |
Revision as of 18:14, 3 December 2008
Calcium-dependent complex between m-calpain and calpastatin
Template:ABSTRACT PUBMED 19020622
About this Structure
3DF0 is a 3 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains., Moldoveanu T, Gehring K, Green DR, Nature. 2008 Nov 20;456(7220):404-8. PMID:19020622
A Ca(2+) switch aligns the active site of calpain., Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL, Cell. 2002 Mar 8;108(5):649-60. PMID:11893336
Calpain silencing by a reversible intrinsic mechanism., Moldoveanu T, Hosfield CM, Lim D, Jia Z, Davies PL, Nat Struct Biol. 2003 May;10(5):371-8. PMID:12665854
Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation., Hosfield CM, Elce JS, Davies PL, Jia Z, EMBO J. 1999 Dec 15;18(24):6880-9. PMID:10601010
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium., Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W, Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):588-92. PMID:10639123
A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor., Todd B, Moore D, Deivanayagam CC, Lin GD, Chattopadhyay D, Maki M, Wang KK, Narayana SV, J Mol Biol. 2003 Apr 18;328(1):131-46. PMID:12684003
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site., Moldoveanu T, Campbell RL, Cuerrier D, Davies PL, J Mol Biol. 2004 Nov 5;343(5):1313-26. PMID:15491615[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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