2z8c

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==About this Structure==
==About this Structure==
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2Z8C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8C OCA].
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2Z8C is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8C OCA].
==Reference==
==Reference==
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Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors., Katayama N, Orita M, Yamaguchi T, Hisamichi H, Kuromitsu S, Kurihara H, Sakashita H, Matsumoto Y, Fujita S, Niimi T, Proteins. 2008 Sep 2;73(4):795-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18767165 18767165]
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<ref group="xtra">PMID:18767165</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
 
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Katayama, N.]]
[[Category: Katayama, N.]]
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[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 20:15:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:08:10 2009''

Revision as of 10:08, 16 February 2009

Image:2z8c.png

Template:STRUCTURE 2z8c

Contents

Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid

Template:ABSTRACT PUBMED 18767165

Disease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670], Coronary artery disease, susceptibility to OMIM:[147545], Diabetes mellitus, noninsulin-dependent OMIM:[147545]

About this Structure

2Z8C is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Katayama N, Orita M, Yamaguchi T, Hisamichi H, Kuromitsu S, Kurihara H, Sakashita H, Matsumoto Y, Fujita S, Niimi T. Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors. Proteins. 2008 Sep 2;73(4):795-801. PMID:18767165 doi:10.1002/prot.22207

Page seeded by OCA on Mon Feb 16 12:08:10 2009

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