2bl6
From Proteopedia
(New page: 200px<br /> <applet load="2bl6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bl6" /> '''SOLUTION STRUCTURE OF THE ZN COMPLEX OF EIA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BL6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BL6 OCA]]. | + | 2BL6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: ZN1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BL6 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: retrovirus zinc finger-like domains]] | [[Category: retrovirus zinc finger-like domains]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:52:25 2007'' |
Revision as of 11:47, 30 October 2007
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SOLUTION STRUCTURE OF THE ZN COMPLEX OF EIAV NCP11(22-58) PEPTIDE, INCLUDING TWO CCHC ZN-BINDING MOTIFS.
Overview
Lentiviral nucleocapsid proteins are a class of multifunctional proteins, that play an essential role in RNA packaging and viral infectivity. They, contain two CX(2)CX(4)HX(4)C zinc binding motifs connected by a basic, linker of variable length. The 3D structure of a 37-aa peptide, corresponding to sequence 22-58 from lentiviral EIAV nucleocapsid protein, NCp11, complexed with zinc, has been determined by 2D (1)H NMR, spectroscopy, simulated annealing, and molecular dynamics. The solution, structure consists of two zinc binding domains held together by a, five-residue basic linker Arg(38)-Ala-Pro-Lys-Val(42) that allows for, spatial proximity between the two finger domains. Observed linker folding, is stabilized by H bonded secondary structure elements, resulting in an, Omega-shaped ... [(full description)]
About this Structure
2BL6 is a [Single protein] structure of sequence from [[1]] with ZN as [ligand]. Structure known Active Site: ZN1. Full crystallographic information is available from [OCA].
Reference
Structural features in EIAV NCp11: a lentivirus nucleocapsid protein with a short linker., Amodeo P, Castiglione Morelli MA, Ostuni A, Battistuzzi G, Bavoso A, Biochemistry. 2006 May 2;45(17):5517-26. PMID:16634633
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