1glo
From Proteopedia
(New page: 200px<br /> <applet load="1glo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1glo, resolution 2.20Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GLO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GLO OCA]]. | + | 1GLO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GLO OCA]]. |
==Reference== | ==Reference== | ||
Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11856830 11856830] | Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11856830 11856830] | ||
| + | [[Category: Cathepsin S]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: thiol proteas]] | [[Category: thiol proteas]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:53:11 2007'' |
Revision as of 11:48, 30 October 2007
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CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S
Overview
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain, superfamily, plays a critical role in the generation of a major, histocompatibility complex (MHC) class II restricted T-cell response by, antigen-presenting cells. Therefore, selective inhibition of this enzyme, may be useful in modulating class II restricted T-cell responses in, immune-related disorders such as rheumatoid arthritis, multiple sclerosis, and extrinsic asthma. The three-dimensional structure at 2.2 A resolution, of the active-site Cys25-->Ser mutant presented here in an unliganded, state provides further insight useful for the design of selective enzyme, inhibitors.
About this Structure
1GLO is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Cathepsin S], with EC number [3.4.22.27]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830
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