1ub4

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(New page: 200px<br /><applet load="1ub4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ub4, resolution 1.70&Aring;" /> '''crystal structure of...)
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[[Image:1ub4.gif|left|200px]]<br /><applet load="1ub4" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ub4.gif|left|200px]]<br /><applet load="1ub4" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1ub4, resolution 1.70&Aring;" />
caption="1ub4, resolution 1.70&Aring;" />
'''crystal structure of MazEF complex'''<br />
'''crystal structure of MazEF complex'''<br />
==Overview==
==Overview==
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A structure of the Escherichia coli chromosomal MazE/MazF addiction module, has been determined at 1.7 A resolution. Addiction modules consist of, stable toxin and unstable antidote proteins that govern bacterial cell, death. MazE (antidote) and MazF (toxin) form a linear heterohexamer, composed of alternating toxin and antidote homodimers, (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from, which two extended C termini project, making interactions with flanking, MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The, MazE/MazF heterohexamer structure documents that the mechanism of, antidote-toxin recognition is common to both chromosomal and plasmid-borne, addiction modules, and provides general molecular insights into toxin, function, antidote degradation in the absence of toxin, and promoter DNA, binding by antidote/toxin complexes.
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A structure of the Escherichia coli chromosomal MazE/MazF addiction module has been determined at 1.7 A resolution. Addiction modules consist of stable toxin and unstable antidote proteins that govern bacterial cell death. MazE (antidote) and MazF (toxin) form a linear heterohexamer composed of alternating toxin and antidote homodimers (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from which two extended C termini project, making interactions with flanking MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The MazE/MazF heterohexamer structure documents that the mechanism of antidote-toxin recognition is common to both chromosomal and plasmid-borne addiction modules, and provides general molecular insights into toxin function, antidote degradation in the absence of toxin, and promoter DNA binding by antidote/toxin complexes.
==About this Structure==
==About this Structure==
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1UB4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UB4 OCA].
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1UB4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UB4 OCA].
==Reference==
==Reference==
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Burley, S.K.]]
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[[Category: Burley, S K.]]
[[Category: Hanaoka, F.]]
[[Category: Hanaoka, F.]]
[[Category: Kamada, K.]]
[[Category: Kamada, K.]]
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[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: addiction module]]
[[Category: addiction module]]
[[Category: antidote]]
[[Category: antidote]]
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[[Category: toxin]]
[[Category: toxin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:58:31 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:31 2008''

Revision as of 13:22, 21 February 2008

Image:1ub4.gif

1ub4, resolution 1.70Å

Drag the structure with the mouse to rotate

crystal structure of MazEF complex

Overview

A structure of the Escherichia coli chromosomal MazE/MazF addiction module has been determined at 1.7 A resolution. Addiction modules consist of stable toxin and unstable antidote proteins that govern bacterial cell death. MazE (antidote) and MazF (toxin) form a linear heterohexamer composed of alternating toxin and antidote homodimers (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from which two extended C termini project, making interactions with flanking MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The MazE/MazF heterohexamer structure documents that the mechanism of antidote-toxin recognition is common to both chromosomal and plasmid-borne addiction modules, and provides general molecular insights into toxin function, antidote degradation in the absence of toxin, and promoter DNA binding by antidote/toxin complexes.

About this Structure

1UB4 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition., Kamada K, Hanaoka F, Burley SK, Mol Cell. 2003 Apr;11(4):875-84. PMID:12718874

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