1ubf
From Proteopedia
(New page: 200px<br /><applet load="1ubf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ubf, resolution 3.50Å" /> '''MsREcA-ATPgS complex...) |
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| - | [[Image:1ubf.jpg|left|200px]]<br /><applet load="1ubf" size=" | + | [[Image:1ubf.jpg|left|200px]]<br /><applet load="1ubf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ubf, resolution 3.50Å" /> | caption="1ubf, resolution 3.50Å" /> | ||
'''MsREcA-ATPgS complex'''<br /> | '''MsREcA-ATPgS complex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structures of Mycobacterium smegmatis RecA (RecA(Ms)) and its | + | The crystal structures of Mycobacterium smegmatis RecA (RecA(Ms)) and its complexes with ADP, ATPgammaS, and dATP show that RecA(Ms) has an expanded binding site like that in Mycobacterium tuberculosis RecA, although there are small differences between the proteins in their modes of nucleotide binding. Nucleotide binding is invariably accompanied by the movement of Gln 196, which appears to provide the trigger for transmitting the effect of nucleotide binding to the DNA-binding loops. These observations provide a framework for exploring the known properties of the RecA proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1UBF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis] with SAP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1UBF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis] with <scene name='pdbligand=SAP:'>SAP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UBF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mycobacterium smegmatis]] | [[Category: Mycobacterium smegmatis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Chandra, N | + | [[Category: Chandra, N R.]] |
[[Category: Datta, S.]] | [[Category: Datta, S.]] | ||
[[Category: Ganesh, N.]] | [[Category: Ganesh, N.]] | ||
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[[Category: recombination]] | [[Category: recombination]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:43 2008'' |
Revision as of 13:22, 21 February 2008
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MsREcA-ATPgS complex
Overview
The crystal structures of Mycobacterium smegmatis RecA (RecA(Ms)) and its complexes with ADP, ATPgammaS, and dATP show that RecA(Ms) has an expanded binding site like that in Mycobacterium tuberculosis RecA, although there are small differences between the proteins in their modes of nucleotide binding. Nucleotide binding is invariably accompanied by the movement of Gln 196, which appears to provide the trigger for transmitting the effect of nucleotide binding to the DNA-binding loops. These observations provide a framework for exploring the known properties of the RecA proteins.
About this Structure
1UBF is a Single protein structure of sequence from Mycobacterium smegmatis with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of Mycobacterium smegmatis RecA and its nucleotide complexes., Datta S, Krishna R, Ganesh N, Chandra NR, Muniyappa K, Vijayan M, J Bacteriol. 2003 Jul;185(14):4280-4. PMID:12837805
Page seeded by OCA on Thu Feb 21 15:22:43 2008
