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Transcription Termination Factor Rho
From Proteopedia
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| - | '''Transcription termination factor Rho''' is a ring-shaped RNA-DNA '''helicase''' that induces release of transcription complexes at specific | + | '''Transcription termination factor Rho''' is a ring-shaped RNA-DNA '''helicase''' that induces release of transcription complexes at specific loci of bacterial genomes. Several structures of Rho in various liganded states haven been solved by X-ray crystallography by the J. M. Berger lab (Berkeley): [[1a8v]], [[1pv4]], [[1pvo]], [[1xpr]], [[1xpu]], [[2a8v]], and [[2ht1]]. |
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| + | The [[Asymmetric Unit|asymmetric unit]] solved as [[2ht1]] contains only two chains, so it represents only one third of the [[Biological unit]], which is a homo-hexamer. | ||
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| + | Here is one representation showing the <scene name='Transcription_Termination_Factor_Rho/Rho_closed_1/3'>Rho hexamer in a closed state</scene>Rho hexamer in a closed state and with RNA fragments occupying both its primary and secondary binding sites. | ||
<applet load='Rho1.pdb' size='300' frame='true' align='right' scene='Transcription_Termination_Factor_Rho/Rho_closed_1/3'> | <applet load='Rho1.pdb' size='300' frame='true' align='right' scene='Transcription_Termination_Factor_Rho/Rho_closed_1/3'> | ||
Revision as of 20:31, 21 November 2008
Transcription termination factor Rho is a ring-shaped RNA-DNA helicase that induces release of transcription complexes at specific loci of bacterial genomes. Several structures of Rho in various liganded states haven been solved by X-ray crystallography by the J. M. Berger lab (Berkeley): 1a8v, 1pv4, 1pvo, 1xpr, 1xpu, 2a8v, and 2ht1.
The asymmetric unit solved as 2ht1 contains only two chains, so it represents only one third of the Biological unit, which is a homo-hexamer.
Here is one representation showing the Rho hexamer in a closed state and with RNA fragments occupying both its primary and secondary binding sites.
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