2k9r

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===Enhancing the activity of insulin by stereospecific unfolding===
===Enhancing the activity of insulin by stereospecific unfolding===
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{{ABSTRACT_PUBMED_19321436}}
==Disease==
==Disease==
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Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], Hyperproinsulinemia, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]], MODY, one form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]]
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Known disease associated with this structure: Hyperproinsulinemia, familial, with or without diabetes OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176730 176730]]
==About this Structure==
==About this Structure==
2K9R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9R OCA].
2K9R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9R OCA].
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==Reference==
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<ref group="xtra">PMID:19321436</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hu, S Q.]]
[[Category: Hu, S Q.]]
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[[Category: Secreted]]
[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:52:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 09:32:58 2009''

Revision as of 06:32, 3 June 2009

Image:2k9r.png

Template:STRUCTURE 2k9r

Contents

Enhancing the activity of insulin by stereospecific unfolding

Template:ABSTRACT PUBMED 19321436

Disease

Known disease associated with this structure: Hyperproinsulinemia, familial, with or without diabetes OMIM:[176730]

About this Structure

2K9R is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem. 2009 May 22;284(21):14586-96. Epub 2009 Mar 25. PMID:19321436 doi:10.1074/jbc.M900085200

Page seeded by OCA on Wed Jun 3 09:32:58 2009

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