1utr
From Proteopedia
(New page: 200px<br /><applet load="1utr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1utr" /> '''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''<br...) |
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| - | [[Image:1utr.jpg|left|200px]]<br /><applet load="1utr" size=" | + | [[Image:1utr.jpg|left|200px]]<br /><applet load="1utr" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1utr" /> | caption="1utr" /> | ||
'''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''<br /> | '''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to | + | Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand. |
==About this Structure== | ==About this Structure== | ||
| - | 1UTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with PCB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1UTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=PCB:'>PCB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Barnes, H | + | [[Category: Barnes, H J.]] |
| - | [[Category: Gustafsson, J | + | [[Category: Gustafsson, J A.]] |
[[Category: Hard, T.]] | [[Category: Hard, T.]] | ||
[[Category: Larsson, C.]] | [[Category: Larsson, C.]] | ||
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[[Category: uteroglobin]] | [[Category: uteroglobin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:16 2008'' |
Revision as of 13:28, 21 February 2008
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UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
Overview
Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
About this Structure
1UTR is a Single protein structure of sequence from Rattus norvegicus with as ligand. Full crystallographic information is available from OCA.
Reference
Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672
Page seeded by OCA on Thu Feb 21 15:28:16 2008
