1v39
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1v39" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v39, resolution 1.8Å" /> '''DC26 MUTANT OF VACCIN...) |
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| - | [[Image:1v39.gif|left|200px]]<br /><applet load="1v39" size=" | + | [[Image:1v39.gif|left|200px]]<br /><applet load="1v39" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1v39, resolution 1.8Å" /> | caption="1v39, resolution 1.8Å" /> | ||
'''DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG'''<br /> | '''DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The specific binding of N7-methylguanine cap analogues to the RNA | + | The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap. |
==About this Structure== | ==About this Structure== | ||
| - | 1V39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with SAH and M7G as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http:// | + | 1V39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=M7G:'>M7G</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V39 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
| - | [[Category: Gershon, P | + | [[Category: Gershon, P D.]] |
| - | [[Category: Hodel, A | + | [[Category: Hodel, A E.]] |
| - | [[Category: Quiocho, F | + | [[Category: Quiocho, F A.]] |
[[Category: M7G]] | [[Category: M7G]] | ||
[[Category: SAH]] | [[Category: SAH]] | ||
| Line 26: | Line 26: | ||
[[Category: vaccinia]] | [[Category: vaccinia]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:31:03 2008'' |
Revision as of 13:31, 21 February 2008
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DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG
Overview
The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
About this Structure
1V39 is a Single protein structure of sequence from Vaccinia virus with and as ligands. Active as Polynucleotide adenylyltransferase, with EC number 2.7.7.19 Full crystallographic information is available from OCA.
Reference
Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102
Page seeded by OCA on Thu Feb 21 15:31:03 2008
