1usl
From Proteopedia
(New page: 200px<br /> <applet load="1usl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1usl, resolution 1.88Å" /> '''STRUCTURE OF MYCOBA...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1USL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.6 5.3.1.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USL OCA]]. | + | 1USL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Ribose-5-phosphate_isomerase Ribose-5-phosphate isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.6 5.3.1.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USL OCA]]. |
==Reference== | ==Reference== | ||
Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site., Roos AK, Andersson CE, Bergfors T, Jacobsson M, Karlen A, Unge T, Jones TA, Mowbray SL, J Mol Biol. 2004 Jan 16;335(3):799-809. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14687575 14687575] | Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site., Roos AK, Andersson CE, Bergfors T, Jacobsson M, Karlen A, Unge T, Jones TA, Mowbray SL, J Mol Biol. 2004 Jan 16;335(3):799-809. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14687575 14687575] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Ribose-5-phosphate isomerase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Andersson, C.E.]] | [[Category: Andersson, C.E.]] | ||
| Line 30: | Line 31: | ||
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:55:34 2007'' |
Revision as of 11:50, 30 October 2007
|
STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RIBOSE-5-PHOSPHATE ISOMERASE, RPIB, RV2465C, COMPLEXED WITH PHOSPHATE.
Overview
Ribose-5-phosphate isomerases (EC 5.3.1.6) inter-convert, ribose-5-phosphate and ribulose-5-phosphate. This reaction allows the, synthesis of ribose from other sugars, as well a means for salvage of, carbohydrates after nucleotide breakdown. Two unrelated types of enzyme, are known to catalyze the isomerization. The most common one, RpiA, is, present in almost all organisms. The second type, RpiB, is found in many, bacterial species.Here, we demonstrate that the RpiB from Mycobacterium, tuberculosis (Rv2465c) has catalytic properties very similar to those, previously reported for the Escherichia coli RpiB enzyme. Further, we, report the structure of the mycobacterial enzyme, solved by molecular, replacement and refined to 1.88A resolution. Comparison with the E.coli, structure shows that ... [(full description)]
About this Structure
1USL is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with PO4 as [ligand]. Active as [Ribose-5-phosphate isomerase], with EC number [5.3.1.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site., Roos AK, Andersson CE, Bergfors T, Jacobsson M, Karlen A, Unge T, Jones TA, Mowbray SL, J Mol Biol. 2004 Jan 16;335(3):799-809. PMID:14687575
Page seeded by OCA on Tue Oct 30 13:55:34 2007
Categories: Mycobacterium tuberculosis | Ribose-5-phosphate isomerase | Single protein | Andersson, C.E. | Jones, T.A. | Mowbray, S.L. | Roos, A.K. | SPINE, Structural.Proteomics.in.Europe. | Unge, T. | PO4 | Isomerase | Pentose phosphate pathway | Phosphopentose isomerase b | Phosphoriboisomerase b | Rv2465c | Spine | Structural genomics | Structural proteomics in europe
