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Sandbox2qc8

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=Glutamine Synthetase: Secondary structures=
Glutamine synthetase is composed of 10 <scene name='Sandbox2qc8/Secondary_structure/1'>identical subunits</scene>.
Glutamine synthetase is composed of 10 <scene name='Sandbox2qc8/Secondary_structure/1'>identical subunits</scene>.

Revision as of 16:02, 17 December 2008

PDB ID 2qc8

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2qc8, resolution 2.60Å ()
Ligands: , , ,
Gene: GLUL, GLNS (Homo sapiens)
Activity: Glutamate--ammonia ligase, with EC number 6.3.1.2
Related: 2ojw
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



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Glutamine Synthetase: Secondary structures

Glutamine synthetase is composed of 10 .

Each subunit has an exposed NH2 terminus and buried COOH terminus as part of a helical thong. [1]

Each subunit is composed predominantly of 12 and 12 , as well as a .

The beta sheets are arranged into two separate partial beta barrels, one of which encompasses the ligand complex.

The active site within the secondary structure can be called a "bifunnel," providing access to ATP and glutamate at opposing ends.[2]


The ligands present are Cl, Mn, Adenosine Diphosphate, and L-Methionine-S-Sulfoximine Phosphate.

References

  1. Yamashita, M., et al.,Refined Atomic Model of Glutamine Synthetase at 3.5A Resolution, The Journal of Biological Chemistry, 1989, 17681-17690.
  2. Eisenberg, D., et al., Structure-function relationships of glutamine synthetases, Biochimica et Biophysica Acta 1477 (2000), 122-145.
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